Submit Manuscript  

Article Details


A Novel Practical Synthesis of Pazopanib: An Anticancer Drug

[ Vol. 9 , Issue. 4 ]

Author(s):

YiCheng Mei, BaoWei Yang, Wei Chen, DanDan Huang, Ying Li, Xin Deng, BaoMing Liu, JingJie Wang, Hai Qian and WenLong Huang   Pages 276 - 279 ( 4 )

Abstract:


This paper reports a novel approach to synthesize pazopanib. In our synthetic route, the potently mutagenic alkylating agents such as dimethyl sulfate and methyl iodide are avoided. A novel regioselective methylation of the 2- position of 3-methyl-6-nitro-1H-indazole was reported. This novel route is one step shorter than the previously reported route.

Keywords:

Anticancer drug, pazopanib, regioselective methylation, synthesis, trimethyl orthoformate, vasculature, dichloropyrimidine, chloride, methylene

Affiliation:

Center of Drug Discovery, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu 210009, P.R. China.



Read Full-Text article