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Magnetic Nanoparticles Catalyzed N-Tert-Butoxycarbonylation of Amines and Amine Derivatives

[ Vol. 9 , Issue. 3 ]


Jafar Akbari, Soghra B. Sajirani, Jafar M. Nezhad and Akbar Heydari   Pages 165 - 168 ( 4 )


A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-butyl dicarbonate using magnetically recoverable γ-Fe2O3@SiO2 nanoparticles is reported. The catalyst can be easily recovered and recycled without a significant loss in the catalytic activity. No competitive side reactions, such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were obsereved.


(Boc)2O, chemoselective, magnetic nanoparticles, protection, recycling, biotechnology, tert-butoxycarbonyl, amine, magnetic field, nanocatalysis


Chemistry Department, Buinzahra Branch, Islamic Azad University, Buinzahra, P. O. Box: 3451686799, Iran.

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