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Triphenylphosphine Catalyzed, One-Pot, Multicomponent Synthesis of Spirooxindoles

[ Vol. 9 , Issue. 2 ]


Syed Riyaz, A. Naidu and Pramod K. Dubey   Pages 101 - 105 ( 5 )


Multicomponent reaction involving isatin (1), malononitrile (2), and dimedone (3), in the presence of triphenylphosphine as an efficient catalyst in the eco-friendly solvent ethanol, results in the formation of spirooxindole derivatives 4 i.e 2-Amino-5-oxo-7,7-dimethyl spiro[(4H)-5,6,7,8-tetrahydrochromene-4,3-(3H)-indol]-(10H)-2-onecarbonitrile. The reaction proceeds smoothly under mild conditions and the products are obtained in good to excellent yields. This method is applicable to a variety of isatin derivatives.


Cyclo addition, multicomponent reaction, spirooxindoles, triphenylphosphine, condensation, ethanol, eco-friendly solvent, acetonitrile, methanol, ethyl acetate


Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Kukatpally, Hyderabad (A.P), 500 085, India.

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