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Efficient and Metal-Free Friedel-Crafts Alkylation of Indoles with Allyl Acetate Mediated by TFE

[ Vol. 7 , Issue. 8 ]

Author(s):

Zhe Liu, Li Liu, Yan-Chao Wu and Dong Wang   Pages 666 - 670 ( 5 )

Abstract:


An efficient, metal-free and chemo-selective Friedel-Crafts allylation of indoles in 2,2,2-trifluoroethanol (TFE) is developed. A possible mechanism has also been discussed to explain the observed competitive pathways in this reaction system.

Keywords:

2,2,2-trifluoroethanol, indole, Friedel-Crafts alkylation, C-3 alkylation, aromatic compounds, benzyl alcohols, Lewis acid, Trifluoroethanol, catalyst, transformation, dimethylindole, regioselectively, alkylation, solvolysis, nucleophilic, indole substrates, chemoselectivity, allyl acetate, hydrogen bond activation, reactivity, solubility, solvent, petroleum ether

Affiliation:

Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China.



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