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Efficient and Metal-Free Friedel-Crafts Alkylation of Indoles with Allyl Acetate Mediated by TFE

[ Vol. 7 , Issue. 8 ]


Zhe Liu, Li Liu, Yan-Chao Wu and Dong Wang   Pages 666 - 670 ( 5 )


An efficient, metal-free and chemo-selective Friedel-Crafts allylation of indoles in 2,2,2-trifluoroethanol (TFE) is developed. A possible mechanism has also been discussed to explain the observed competitive pathways in this reaction system.


2,2,2-trifluoroethanol, indole, Friedel-Crafts alkylation, C-3 alkylation, aromatic compounds, benzyl alcohols, Lewis acid, Trifluoroethanol, catalyst, transformation, dimethylindole, regioselectively, alkylation, solvolysis, nucleophilic, indole substrates, chemoselectivity, allyl acetate, hydrogen bond activation, reactivity, solubility, solvent, petroleum ether


Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China.

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