Submit Manuscript  

Article Details

One-Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent

[ Vol. 7 , Issue. 8 ]


Dahong Jiang and Yuanwei Chen   Pages 661 - 665 ( 5 )


A highly efficient route to substituted furans from readily available 5-hydroxymethyl-substituted Δ2- isoxazolines is described. The transformation involves sequential reduction/hydrolysis/cyclocondensation in a one-pot reaction using iron as reducing agent under mild conditions.


Furan, isoxazoline, iron, reduction, optoelectronic, natural products, cyclocondensation, catalytic hydrogenation, 2-isoxazolines, hydroxy ketones, N, –, O bond cleavage, hydroxyimine, cyclodehydration, HCl, HOAc, reaction temperature, vinyl groups, acetic acid, solvents, NMR, CDCl3, MgSO4


Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, P. R. of China.

Read Full-Text article