Dahong Jiang and Yuanwei Chen Pages 661 - 665 ( 5 )
A highly efficient route to substituted furans from readily available 5-hydroxymethyl-substituted Δ2- isoxazolines is described. The transformation involves sequential reduction/hydrolysis/cyclocondensation in a one-pot reaction using iron as reducing agent under mild conditions.
Furan, isoxazoline, iron, reduction, optoelectronic, natural products, cyclocondensation, catalytic hydrogenation, 2-isoxazolines, hydroxy ketones, N, –, O bond cleavage, hydroxyimine, cyclodehydration, HCl, HOAc, reaction temperature, vinyl groups, acetic acid, solvents, NMR, CDCl3, MgSO4
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, P. R. of China.