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One-Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent

[ Vol. 7 , Issue. 8 ]

Author(s):

Dahong Jiang and Yuanwei Chen   Pages 661 - 665 ( 5 )

Abstract:


A highly efficient route to substituted furans from readily available 5-hydroxymethyl-substituted Δ2- isoxazolines is described. The transformation involves sequential reduction/hydrolysis/cyclocondensation in a one-pot reaction using iron as reducing agent under mild conditions.

Keywords:

Furan, isoxazoline, iron, reduction, optoelectronic, natural products, cyclocondensation, catalytic hydrogenation, 2-isoxazolines, hydroxy ketones, N, –, O bond cleavage, hydroxyimine, cyclodehydration, HCl, HOAc, reaction temperature, vinyl groups, acetic acid, solvents, NMR, CDCl3, MgSO4

Affiliation:

Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, P. R. of China.



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