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Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21-C26 Segment

[ Vol. 7 , Issue. 8 ]

Author(s):

Rita Pal, Hasibur Rahaman, D. K. Mohapatra and Mukund K. Gurjar   Pages 657 - 660 ( 4 )

Abstract:


The synthesis of C21-C26 fragment of superstolide A, starting from D-glucose diacetonide, involving regioselective ring opening of epoxide by Grignard reagent and regioselective stereospecefic hydroboration oxidation has been described.

Keywords:

Superstolide A, Potent cytotoxic, Chiral pool, Regioselective epoxide opening, Stereoselective hydroborationoxidation, Carbohydrate, C21-C26, Grignard reagent, Neosiphonia superstes, polyketide, D-glucose diacetonide, hydroboration oxidation, tosylation, alcohol, epoxidation, benzyl ether, Cleavage, methanolic HCl, hydroxyl group, Oxidative cleavage, CuCN, PDC oxidation, selectively, Debenzylation, BBN, PMB, mesylation, azido, compound

Affiliation:

Organic Chemistry Division, National Chemical Laboratory, Pune-411008, India.



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