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FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)&#

[ Vol. 2 , Issue. 4 ]

Author(s):

Palakodety Radha Krishna, B. Lavanya, A. K. Mahalingam, V.V. Ramana Reddy and G. V.M. Sharma   Pages 360 - 363 ( 4 )

Abstract:


Anhydrous FeCl3 and FeCl3-SiO2 serve as Lewis acids for direct conversion of alcohols into pmethoxybezyl ethers using PMB-OH in good yields, the latter reagent was found to be effective in not only converting primary, allylic and propargylic alcohols selectively but also the pre-existing acid sensitive groups remained unscathed.

Keywords:

deprotection, benzyl ethers, p-methoxybenzyl (pmb), catalytic ddq, nucleophilic attack, lewis acid, pmb alcohol

Affiliation:

D 206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India.



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