Grigorii G. Sivets, Jouko Vepsalainen and Igor A. Mikhailopulo Pages 343 - 348 ( 6 )
1-Methanesulfonyloxy-2-methoxyethane (1; MsO-MOE) was used for alkylation of adenosine and 2-aminoadenosine. 2-O-MOE derivatives of adenosine (3), 2-aminoadenosine (7) and guanosine (10) have been prepared in 47, 44 and 81% isolated yields, respectively. The stereochemistry of the pentofuranose rings of the isomeric 2-O-MOE and 3-O-MOE purine nucleosides is very similar and, moreover, alkylation of either 2- or 3-hydroxyls has practically no effect upon the stereochemistry of the parent nucleosides.
nucleosides, purine, o-moe derivatives, methanesulfonyloxy-methoxyethane, stereochemistry
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