Submit Manuscript  

Article Details

Highly Stereoselective Alkynylation with Steroidal Alkyne: Efficient Pathway to 24(S) or 24(R)-Hydroxylcholesterol

[ Vol. 2 , Issue. 4 ]


Biao Jiang, Zi-li Chen and Hao Huang   Pages 319 - 322 ( 4 )


24(S)- or 24(R)-Hydroxyl cholesterol was prepared in high stereoselectivity (up to 99% de), utilizing asymmetric alkynylation of isobutyraldehyde with steroidal alkyne catalyzed by Zn(OTf)2 respectively in the presence of (1S, 2S)-3-(t-butyldimethylsilyloxyl)-2-N, N-dimethylamino-1-(p-nitrophenyl)- propane-1-ol or its (1R, 2R)-enantiomer.


asymmetric alkynylation, hydroxylcholesterol, hyodeoxycholic acid


Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China.

Read Full-Text article