Marta Galobardes, Miguel Gascon, Pedro Romea and Felix Urpi Pages 312 - 315 ( 4 )
A new synthetic approach directed toward the preparation of C1-C6 fragment of erythronolides is disclosed. The core of the process takes advantage of a highly stereoselective sequence based on a boron- mediated aldol reaction of a lactate-derived chiral ketone followed by a syn-reduction of the resulting adduct.
aldol reaction, boron enolates, chiral ketones, erythronolides, stereoselective synthesis
Departament de Quimica Organica, Universitat de Barcelona, Marti i Franques 1-11, 08028 Barcelona, Catalonia, Spain.