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A Stereoselective Aldol-Reduction Approach to Polyoxygenated Natural Products. Synthesis of C1-C6 Fragment of Erythronolides

[ Vol. 2 , Issue. 4 ]

Author(s):

Marta Galobardes, Miguel Gascon, Pedro Romea and Felix Urpi   Pages 312 - 315 ( 4 )

Abstract:


A new synthetic approach directed toward the preparation of C1-C6 fragment of erythronolides is disclosed. The core of the process takes advantage of a highly stereoselective sequence based on a boron- mediated aldol reaction of a lactate-derived chiral ketone followed by a syn-reduction of the resulting adduct.

Keywords:

aldol reaction, boron enolates, chiral ketones, erythronolides, stereoselective synthesis

Affiliation:

Departament de Quimica Organica, Universitat de Barcelona, Marti i Franques 1-11, 08028 Barcelona, Catalonia, Spain.



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