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Effect of Additional Chiral Ligands in Catalytic Enantioselective Addition of Ketene Silyl Acetals to Nitrones

[ Vol. 2 , Issue. 4 ]

Author(s):

P. Merino, S. Franco, P. Jimenez, T. Tejero and M. A. Chiacchio   Pages 302 - 305 ( 4 )

Abstract:


The enantioselectivity of the titanium (IV)-BINOL catalyzed asymmetric Mannich-type reactions of nitrones can be enhanced by using additional chiral ligands. The best results are obtained with diols derived from D-mannitol.

Keywords:

nitrones, hydroxylamines, aminoacids, mannich reaction

Affiliation:

Departamento de Quimica Organica, Facultad de Ciencias-ICMA, Universidad de Zaragoza-CSIC,E-50009 Zaragoza, Aragón, Spain.



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