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Recent Advances in Transition Metal Mediated Synthetic Approaches to Quinoline Derivatives

[ Vol. 18 , Issue. 9 ]

Author(s):

Rukhsana Tabassum*, Muhammad Ashfaq and Hiroyuki Oku   Pages 669 - 686 ( 18 )

Abstract:


Synthesis of heterocyclic compounds containing quinoline scaffold gained significant attention of organic chemists due to their importance as a therapeutic agent in the pharmaceutical industry. Quinoline molecules exhibit extensive biological activities, a few of which are antiviral, anti-inflammatory antibacterial, antifungal, antiproliferative, anthelmintic and anticonvulsant. A variety of synthetic routes has been developed for construction compounds bearing the quinoline nucleus due to its broad spectrum of pharmacological activities. This review describes recent development in transition metal mediated synthetic protocols of these important heterocycles by the formation of quinoline rings or by substitution of quinoline rings, including both modified conventional name reactions and novel routes with highly functionalized quinoline products.

Keywords:

Quinoline, quinoline derivatives, transition metal, catalyst, heterocyclic, synthesis.

Affiliation:

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 36100, Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 36100, Division of Molecular Science, Graduate School of Science &Engineering Gunma University, Gunma 376-8515

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