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Bentonite Catalyzed an Efficient and Green Synthesis of Arylidene Meldrum's Acid Derivatives in Aqueous Media

[ Vol. 18 , Issue. 7 ]

Author(s):

Mahdieh Yahyazadehfar, Sayed Ali Ahmadi*, Enayatollah Sheikhhosseini and Dadkhoda Ghazanfari   Pages 513 - 519 ( 7 )

Abstract:


In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available non-toxic mineral catalyst exposed to aqueous media under green conditions. Together with the substitution protocol of electron-donating or -withdrawing groups, all reactions were finalized from 5 to 120 min in water at 90°C. With regard to such reactions, the purification of columns on products was not a requirement. Considering the environmental aspect, use of water as a green solvent, utilization of a reusable catalyst, simple work-up process and steps, as well as rapid reaction times were taken into account as some characteristics of these chemical reactions.

Keywords:

Arylidene Meldrum’s acid, Bentonite (Al2O3.4SiO.H2), Knoevenagel condensation, aqueous media, natural catalyst, electron-donating.

Affiliation:

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman



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