Ramamurthy Katikireddy, Ramu Kakkerla *, M.P.S. Murali Krishna, Gandamalla Durgaiah and Y.N. Reddy Pages 959 - 968 ( 10 )
A series of benzimidazolyl-1,3,4-oxadiazoles (7a-k) were synthesized and evaluated for in vitro anticancer activity against HeLa, MCF7, A549, and HEK293 cell lines. The results indicate that compounds 7b, 7j and 7k have shown excellent anticancer activity and while most of the compounds were non toxic to normal HEK293 cell lines. Molecular docking results of the synthesized compounds with the target Pin1 protein were also discussed.
5-Substituted benzimidazoles, benzimidazolyl oxadiazoles, MTT assay, anticancer activity, molecular docking studies.
Department of Chemistry, JNTUK, Kakinda, Andhra Pradesh- 533003, Department of Chemistry, Satavahana University, Karimnagar, Telangana State-505001, Department of Chemistry, Andhra Polytechnic College, Kakinada, Andhra Pradesh- 533003, Department of Pharmacology and Toxicology, Kakatiya University, Warangal, Telangana State- 506009, Department of Pharmacology and Toxicology, Kakatiya University, Warangal, Telangana State- 506009