Cu-Catalyzed Cascade Reaction of Isoxazoles with Diaryliodonium Salts for the Synthesis of Acridines

Author(s):

Shangrong Zhu, Xuechen Lu, Qiuneng Xu, Jian Li* and Shenghu Yan*   Pages 944 - 950 ( 7 )

Abstract:

A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has gone through tandem double arylation and Friedel-Crafts reactions.

Keywords:

Synthetic methods, Cu-Catalyzed, Cascade Reaction, Diaryliodonium salts, Isoxazole, Acridine.

Affiliation:

School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164

Graphical Abstract:

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