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Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings

[ Vol. 17 , Issue. 11 ]

Author(s):

Shaik Shahinshavali, Nuthalapati Poojith, Venkat Rao Guttikonda, Reddymasu Sreenivasulu and Mandava Venkata Basaveswara Rao*   Pages 864 - 871 ( 8 )

Abstract:


We have synthesized a library of new 1,2,3-triazole incorporated 1,3,4-thiadiazoleisothiazolo[ 4,3-b]pyridine derivatives 12a-j and have screened these products for their anticancer activities against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer), and MDA MB-231 (breast cancer) using MTT assay with etoposide as a positive control. Among them, compound 12e has shown excellent activities against MCF-7, A549, DU-145, and MDA-MB-231 with IC50 values of 0.53±0.055 μM, 0.18±0.077 μM, 0.10±0.082 μM, and 0.92±0.041 μM, respectively.

Keywords:

1, 2, 3-triazole, 1, 3, 4-thiadiazole, anticancer activity, azetepa, Carboxyamido triazole (CAI), isothiazolo[4, 3- b]pyridine.

Affiliation:

Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001, Sri Ramachandra Institute of Higher Education and Research, Ramachandra Nagar, Porur, Chennai, 600116, Tamilnadu, Department of Chemistry, SRR and CVR Government Degree College (Autonomous), Vijayawada, Andhra Pradesh, 520004, Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001



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