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An Effective Assembling of Novel Derivatives Containing Both Benzo[d]thiazole and Benzo[d]oxazole Rings

[ Vol. 17 , Issue. 11 ]

Author(s):

Nguyen Thi Ngoc Mai, Duong Quoc Hoan*, Vu Thi Anh Tuyet, Tran Thi Thu Trang, Duong Khanh Linh and Trinh Thi Huan   Pages 815 - 822 ( 8 )

Abstract:


A novel series of 5-(benzo[d]thiazol-2-yl)benzo[d]oxazole-based compounds was synthesized in four linear steps in high yield from vanillin. Both benzo[d]thiazole and benzo[d]oxazole cyclizations were assisted with a domestic microwave oven in about 4-8 minutes in which the yield of the benzo[d]oxazole cyclization was up to 92%. Structures of the new synthesized compounds were elucidated by spectral data.

Keywords:

Benzo[d]thiazole, benzo[d]oxazole, microwave, vanillin, cyclization, formylation reaction.

Affiliation:

Department of Science, Hong Duc University, Thanh Hoa, Department of Chemistry, Hanoi National University of Education, Hanoi, Department of Science, Lang Son College of Education, Lang Son City, Department of Chemistry, Hanoi National University of Education, Hanoi, Department of Chemistry, Hanoi National University of Education, Hanoi, Department of Science, Hong Duc University, Thanh Hoa



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