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Synthesis of a New Dioxaspiro[bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]deca- 1(10),8-dien-4-one Derivative Using Some Chemical Strategies

[ Vol. 17 , Issue. 5 ]

Author(s):

Figueroa-Valverde Lauro*, Rosas-Nexticapa Marcela, Lopez-Ramos Maria, Diaz Cedillo Francisco, Mateu-Armand Virginia, Garcimarero-Espino E. Alejandra, Borges-Ballote Yaritza and Ortiz-Ake Yazmin   Pages 393 - 402 ( 10 )

Abstract:


There are several protocols for the preparation of bicyclic derivatives; however, some methods use dangerous and require special conditions. The aim of this study was to synthesize a new Dioxaspiro[ bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]-deca-1(10), 8-dien-4-one (compound 8). Compound 8 was prepared using some reactions such as; i) etherification, ii) reduction, iii) amidation, iv) imination and v) 2+2 addition. The chemical structure of 8 and its intermediaries were completely characterized by spectroscopic techniques and elemental analysis. The synthesis showed a yield of 85% for compound 8. In this study, an easy method for the preparation of compound 8 is reported.

Keywords:

Steroid, bicyclo, dioxaspiro, etherification, reduction, dienone.

Affiliation:

Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche, Facultad de Nutricion, Universidad Veracruzana. Medicos y Odontologos s/n, 91010, Xalapa, Veracruz, Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche, Escuela Nacional de Ciencias Biologicas del Instituto Politecnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, Facultad de Nutricion, Universidad Veracruzana. Medicos y Odontologos s/n, 91010, Xalapa, Veracruz, Facultad de Medicina, Universidad Veracruzana. Medicos y Odontologos s/n, 91010, Xalapa, Veracruz, Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche, Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche

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