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Design, Synthesis and Biological Evaluation of 3-(3,4,5-Trimethoxyphenyl)- 5-(2-(5-arylbenzo[b]thiophen-3-yl)oxazol-5-yl)isoxazole Derivatives as Anticancer Agents

[ Vol. 17 , Issue. 5 ]

Author(s):

Syndla Premalatha, G. Rambabu, Islavathu Hatti and Dittakavi Ramachandran*   Pages 345 - 351 ( 7 )

Abstract:


A new series of 3-(3,4,5-trimethoxyphenyl)-5-(2-(5-arylbenzo[b]thiophen-3-yl)oxa zol-5- yl)isoxazole derivatives were designed and synthesized. All these derivatives were evaluated for their anticancer activity against various human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer) and MDA MB-231 (breast cancer)-four human cancer cell lines by using MTT assay. Here, etoposide was used as a standard reference drug and most of the compounds were exhibited good anticancer activity with respect to cell lines. Among all compounds, five compounds 11b, 11c, 11f, 11i and 11j showed more potent activity than standard drug, in which, compound 11f was the most promising compound.

Keywords:

Isoxazole, raloxifene, MTT assay, anticancer activity, MCF-7, prostate cancer.

Affiliation:

Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar - 522 510, Andhra Pradesh, Centre for Applied Science, Department of Basic Sciences & Humamities, Division of Chemistry, Sri Vidyanikethan Engineering College (Autonomous), Tirupati - 517 102, Andhra Pradesh, Department of Chemistry, Jagarlamudi Kuppuswamy Choudary College, Guntur - 522 006, Andhra Pradesh, Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar - 522 510, Andhra Pradesh

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