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OctaGel Resin - A New PEG-PS-based Solid Support for Solid-Phase Peptide Synthesis

[ Vol. 16 , Issue. 12 ]

Author(s):

Shaveer Ramkisson, Yahaya E. Jad, Anamika Sharma, Beatriz G. de la Torre* and Fernando Albericio*   Pages 935 - 940 ( 6 )

Abstract:


OctaGel resin is a unique, highly uniformed surface-active resin. Here, we compared the performance of OctaGel with that of known resins on the market, namely polystyrene and ChemMatrix, in Solid-Phase Peptide Synthesis. The synthesis of the ‘difficult’ Aib-ACP (65-74) decapeptide showed that OctaGel has the potential to yield molecules with satisfactory purity. Given its high swelling capacity and large bead size, OctaGel also shows efficient interaction with various solvents, including those mainly used for SPPS (DMF and DCM).

Keywords:

Solid-phase peptide synthesis, OctaGel resin, polystyrene resin, Chem matrix, ACP-decapeptide, SEM.

Affiliation:

School of Chemistry and Physics, University of KwaZulu Natal, Private bag X54001, Westville campus, Durban, South Africa, 4000, School of Chemistry and Physics, University of KwaZulu Natal, Private bag X54001, Westville campus, Durban, South Africa, 4000, School of Chemistry and Physics, University of KwaZulu Natal, Private bag X54001, Westville campus, Durban, South Africa, 4000, KRISP, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa, 4001, School of Chemistry and Physics, University of KwaZulu Natal, Private bag X54001, Westville campus, Durban, South Africa, 4000



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