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Synthesis of Highly Functionalized Quinazoline-2,4(1H,3H)-diones from Isocyanides, Aniline and Isocyanate via Cu-Catalyzed Intermolecular C-H Activation Reactions

[ Vol. 17 , Issue. 11 ]

Author(s):

Manijeh Nematpour, Hossein Fasihi Dastjerdi, Mehdi Jahani and Sayyed Abbas Tabatabai*   Pages 832 - 836 ( 5 )

Abstract:


A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials- catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically (1H- and 13C-NMR, IR and EI-MS) and by elemental analyses.

Keywords:

C-H Activation, isocyanate, Cu-catalyzed, quinazoline-2, 4(1H, 3H)-diones, isocyanides, aniline.

Affiliation:

Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Department of Chemistry, Sharif University of Technology, Tehran, Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran



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