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Design, Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Bearing Isoxazole-Pyrazole Derivatives

[ Vol. 17 , Issue. 5 ]

Author(s):

Bhukya Ravinaik , Dittakavi Ramachandran * and Mandava Venkata Basaveswara Rao   Pages 352 - 359 ( 8 )

Abstract:


A novel library of 1,2,4-oxadiazole bearing isoxazole-pyrazole derivatives (13a-j) were designed, synthesized and evaluated for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer) and MDA MB-231 (breast cancer) human cancer cell lines by MTT assay. Here etoposide used as standard drug. Among them, five compounds (13b, 13c, 13d, 13h and 13i) were exhibited more potent activity. In which compound 13h was the most promising compound against all cell lines MCF-7, A549, DU-145 and MDA MB-231.

Keywords:

SR141716A, proxazole, pyrazole, 1, 2, 4-oxadiazole and anticancer activity, MCF-7 (beast cancer), MDA MB-231.

Affiliation:

Department of Chemistry, Krishna University, Machilipatnam - 521 001, Andhra Pradesh, Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar - 522 510, Andhra Pradesh, Department of Chemistry, Dr. MRAR. PG Centre, Krishna University, Nuzvid - 521 201, Andhra Pradesh



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