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Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity

[ Vol. 17 , Issue. 3 ]

Author(s):

Ty Viet Pham, Thang Quoc Le , Anh Tuan Le , Hung Quoc Vo and Duc Viet Ho*   Pages 206 - 210 ( 5 )

Abstract:


A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

Keywords:

Annona reticulata, Annonaceae, pimarane-type diterpene, flavonoid, cytotoxicity, SK-LU-1, SW626.

Affiliation:

Faculty of Chemistry, Hue University of Education, Hue University, 34 Le Loi, Hue City, Faculty of Chemistry, Hue University of Education, Hue University, 34 Le Loi, Hue City, Quang Tri Center of Science and Technology, Mientrung Institute for Scientific Research, VAST, Dien Bien Phu, Dong Ha, Quang Tri, Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City

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