Submit Manuscript  

Article Details


Synthesis and Evaluation of Isatin Derivatives as Antifungal Agents

[ Vol. 17 , Issue. 3 ]

Author(s):

Monika Dawar , Divya Utreja*, Ritu Rani and Komalpreet Kaur   Pages 199 - 205 ( 7 )

Abstract:


Various types of isatin derivatives were synthesized by reacting isatin with different reagents viz substituted acetophenones, sodium nitrate, hydroxylamine hydrochloride and hydrazine hydrate. Characterization of the synthesized compounds was done by using various spectral techniques such as IR, 1HNMR, 13CNMR, elemental analysis and mass spectrometry. Synthesized compounds were further evaluated for their antifungal activity against Helminthosporium oryzae, Rhizoctonia solani and Fusarium moniliforme using poison food technique. 3-(2-Oxo-2-phenylethylidene) indolin- 2-one showed significant mycelium inhibition against all tested rice fungi.

Keywords:

Isatin, antifungal activity, poison food technique, Helminthosporium oryzae, Rhizoctonia solani and Fusarium moniliforme, acetophenones.

Affiliation:

Department of Chemistry, Punjab Agricultural University, Ludhiana-141004 (Punjab), Department of Chemistry, Punjab Agricultural University, Ludhiana-141004 (Punjab), Department of Plant Pathology, Punjab Agricultural University, Ludhiana-141004 (Punjab), Department of Chemistry, Punjab Agricultural University, Ludhiana-141004 (Punjab)

Graphical Abstract:



Read Full-Text article