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Novel 1,3,4-Thiadiazole Linked Amide Derivatives of Pteridone: Synthesis and Study of Anticancer Activities

[ Vol. 17 , Issue. 1 ]

Author(s):

Eeduri R. Devi, Reddymasu Sreenivasulu, Koya P. Rao, Ratnakaram V. Nadh and Malladi Sireesha*   Pages 54 - 60 ( 7 )

Abstract:


Cancer is a second leading cause of death after heart attack, in developing as well as undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal cancer cells. Cancer can be cured by radiation, immunotherapy and chemotherapy, among them; chemotherapy is a good treatment for cancer, in which chemotherapeutic drug is used. The anticancer activity of newly synthesized compounds (13a-j) was carried out on four different types of human cancer cell lines like MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by the MTT method, and compared to etoposide used as a positive control. Among them, compound 13g with electron-withdrawing (3,5-dinitro) group, exhibited more promising activity in all cell lines (MCF-7 = 0.10±0.076 µM, A549 = 0.17±0.039 µM, Colo-205= 0.13±0.022 µM and A2780 = 0.87±0.027µM). This compound may act as lead drug in cancer chemotherapy. In future, this compound can be examined for clinical studies.

Keywords:

Pteridone, pralatrexate, triamterene, thiamethoxam, anticancer activity, cancer.

Affiliation:

Division of Chemistry, Department of Science & Humanities, Vignan's Foundation for Science, Technology and Research" (Deemed to be University), Vadlamudi - 522 213, Guntur, Andhra Pradesh, Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada - 533 003, Andhra Pradesh, Division of Chemistry, Department of Science & Humanities, Vignan's Foundation for Science, Technology and Research" (Deemed to be University), Vadlamudi - 522 213, Guntur, Andhra Pradesh, Department of Chemistry, Gandhi Institute of Technology and Management (Deemed to be University), Bangalore Campus- 561 203, Karnataka, Division of Chemistry, Department of Science & Humanities, Vignan's Foundation for Science, Technology and Research" (Deemed to be University), Vadlamudi - 522 213, Guntur, Andhra Pradesh

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