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Efficient Route for Synthesis of Enamines from 1,3-alkyl-2- Thioxodihydropyrimidine-4,6(1H,5H)-dione Enols

Author(s):

Anamika Sharma, Zainab M. Almarhoon, Ayman El-Faham*, Beatriz G. de la Torre* and Fernando Albericio   Pages 1 - 3 ( 3 )

Abstract:


Here we report a greener approach for the synthesis of enamines from enols of thiobarbituric acid using ammonium chloride and ethanol as solvent. This protocol removes the need for catalysts or harsh conditions.

Keywords:

Thiobarbituric acid, enols, enamines, greener approach, ammonium chloride, HPLC

Affiliation:

School of Health Sciences, College of Health Sciences, University of KwaZulu Natal, University Road, Westville, Durban 4000, Department of Chemistry, College of Science, King Saud University, 2455, Riyadh, Saudi Arabia, 11451, Department of Chemistry, College of Science, King Saud University, 2455, Riyadh, Saudi Arabia, 11451, KRISP, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa, 4001, Department of Chemistry, College of Science, King Saud University, 2455, Riyadh, Saudi Arabia, 11451



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