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Efficient Route for Synthesis of Enamines from 1,3-Alkyl-2-Thioxodihydropyrimidine-4,6(1H,5H)-dione Enols

[ Vol. 16 , Issue. 7 ]

Author(s):

Anamika Sharma, Zainab M. Almarhoon, Ayman El-Faham*, Beatriz G. de la Torre* and Fernando Albericio*   Pages 538 - 540 ( 3 )

Abstract:


Here we report a greener approach for the synthesis of enamines from enols of 1,3-alkyl-2- thioxodihydropyrimidine-4,6(1H,5H)-dione (thiobarbituric acid) acid using ammonium chloride and ethanol as solvents. This protocol removes the need for catalysts or harsh conditions.

Keywords:

Thiobarbituric acid, enols, enamines, greener approach, ammonium chloride, HPLC.

Affiliation:

School of Health Sciences, College of Health Sciences, University of KwaZulu Natal, University Road, Westville, Durban 4000, Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Department of Chemistry, College of Science, King Saud University, Riyadh 11451, KRISP, College of Health Sciences, University of KwaZulu Natal, Durban 4001, Department of Chemistry, College of Science, King Saud University, Riyadh 11451

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