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Efficient and Regioselective Ring-opening of Epoxides with Carboxylic Acid Catalyzed by Graphite Oxide

[ Vol. 17 , Issue. 7 ]

Author(s):

Maryam Mirza-Aghayan*, Mahdieh Molaee Tavana, Elaheh Golam Alipour Niazi and Rabah Boukherroub   Pages 532 - 538 ( 7 )

Abstract:


An efficient, simple and regioselective ring-opening reaction of epoxides with various carboxylic acids under metal-free conditions is reported. The ring-opening of epoxides takes place in the presence of graphite oxide as an efficient and available catalyst to produce the corresponding 2-hydroxy monoester and 1,2-diester derivatives in good yields. Regioselective attack of the nucleophile, short reaction times, metal-free conditions and reusability of catalyst are among the advantages of the present protocol.

Keywords:

Ring-opening, epoxides, carboxylic acids, metal-free conditions, graphite oxide, 1, 2-diester.

Affiliation:

Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P. O. BOX 14335-186, Tehran, Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P. O. BOX 14335-186, Tehran, Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P. O. BOX 14335-186, Tehran, Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille

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