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Ultrasonic Assisted Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones Involving Three-Component Reaction of Isatoic Anhydride, Amines and Pyrazole Carbaldehydes Catalyzed by [γ-Fe2O3@HAp-SO3H]

[ Vol. 17 , Issue. 1 ]

Author(s):

Kiana F. Sina, Asieh Yahyazadeh*, Nosrat O. Mahmoodi, Kurosh R. Moghadam, Mohammad Nikpassand and Mahdi Rasa   Pages 24 - 30 ( 7 )

Abstract:


The combination of [γ-Fe2O3@HAp-SO3H] as a catalyst and ultrasonic effect catalyzed the synthesis of diverse derivatives of 2, 3-dihydroquinazolin-4(1H)-ones which is reported in this study. The products were synthesized via the one-pot three-component reaction of isatoic anhydride, amines and pyrazole carbaldehydes in water: EtOH catalyzed by recoverable [γ-Fe2O3@HAp-SO3H]. This paper conducted an investigation of the effect of various solvents, temperatures and catalysts on the reactions. Short reaction times, mild reaction conditions, simple work-up, the desired yields and the use of an appropriate catalyst are the advantages of this novel method. The new derivatives were validated by using FT-IR, 1HNMR, and 13CNMR. Moreover, the synthesized compounds were screened for their antimicrobial activity against bacterial strains.

Keywords:

2, 3-Dihydroquinazolinone, pyrazole carbaldehydes, ultrasonic, [γ-Fe2O3@HAp-SO3H], catalyst, one-pot threecomponent reaction.

Affiliation:

Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht

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