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Ultrasonic Assisted Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Involving Three-Component Reaction of Isatoic Anhydride, Amines and Pyrazole Carbaldehydes Catalyzed by [Ɣ-Fe2O3@HAP-SO3H]

Author(s):

Kiana Faraji Sina, Asieh Yahyazadeh*, Nosrat Ollah Mahmoodi, Kurosh Rad Moghadam, Mohammad Nikpassand and Mahdi Rasa   Pages 1 - 7 ( 7 )

Abstract:


The combination of [Ɣ-Fe2O3@HAP-SO3H] as a catalyst and ultrasonic effect catalyzed the synthesis of diverse derivatives of 2,3-dihydroquinazolin-4(1H)-ones which is reported. The products synthesized via the one-pot three-component reaction of isatoic anhydride, amines and pyrazole carbaldehydes in water: EtOH catalyzed by recoverable [Ɣ-Fe2O3@HAP-SO3H]. This paper indicates an investigation of the effect of various solvents, temperatures and catalysts on the reactions. Short reaction times, mild reaction conditions, simple work-up, desired yields and the use of an appropriate catalyst are the advantages of this novel method. The new derivatives confirmed by using FT-IR, 1HNMR, 13CNMR. The synthesized compounds screened for their antimicrobial activity against bacterial strains.

Keywords:

2, 3-Dihydroquinazolinone- Pyrazole Carbaldehydes- Ultrasonic- [Ɣ-Fe2O3@HAP-SO3H].

Affiliation:

Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, , Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, , Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, , Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, , Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht



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