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Antioxidant Properties of Synthesis Nanometallic Pd-Ni@2- Mercaptoethanol as Effective Catalyst for Suzuki-Miyaura Reactions

Author(s):

Khemais Said*, Ali Mesni and Ridha Ben Salem   Pages 1 - 10 ( 10 )

Abstract:


The palladium-catalyzed Suzuki coupling reaction is one of the most efficient strategies for constructing a carbon–carbon bond. In recent years, bimetallic catalysts have become candidates for the Suzuki coupling reaction. In this work, Pd-Ni@2-Mercaptoethanol nanoparticles were synthesized for the Suzuki-Miyaura cross-coupling of arylboronic acids with aryl bromides, in the N,N-dimethylformamide/water mixture catalyzed by Pd-Ni: A simple and efficient reaction performed in a solvent, without a ligand, and in open air. We found that the Suzuki-Miyaura reactions are remarkably fast (5 min), with high yields and the products are highly pure. The Pd-Ni@2-Mercaptoetanol nanoparticles have a narrow size distribution with a mean crystallite size of 10 nm. Radical scavenging activities of the complexes have been evaluated by using DPPH, DMPD+ and ABTS+ assays. IC50 values (μg/ml) of the complexes and standards on DPPH, DMPD+ and ABTS+ respectively follow the sequences.

Keywords:

Nanoparticles, Suzuki C-C Coupling, ROS scavenging activities, Ultrasound, Arylboronic acids, Biaryls

Affiliation:

Organic Chemistry Laboratory (LR17ES08), University of Sfax, Sciences Faculty of Sfax, 3018, Sfax, Laboratory of Bio-Active Substances, Department of Life Sciences, University of Carthage, Science Faculty of Bizerte, Zarzouna 7021, Bizerte, Organic Chemistry Laboratory (LR17ES08), University of Sfax, Sciences Faculty of Sfax, 3018, Sfax



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