Mohammad Reza Poor Heravi*, Mahdis Danafar and Niloofar Poor Heravi Pages 922 - 930 ( 9 )
An expeditious three-component synthesis of various biologically important heterocyclic compounds 5-amino-1,3-diaryl-1H-pyrazole-4-carbonitriles by condensation of aryl aldehydes, malononitrile and phenylhydrazine derivatives is described. This greener protocol was catalyzed by L-Proline and proceeded efficiently in solvent at room temperature within 2-15 min.
Multicomponent reactions, 1H-pyrazole-4-carbonitriles, L-proline, antimicrobial activity, one-pot of threecomponent, organocatalyst.
Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Department of Biochemistry, School of Medicine, Anzali International Campus, Guilan University of Medical Sciences, Rasht