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Antimicrobial Activity and Reactions of 4-benzoyl-1-(-4-methoxyphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

Author(s):

Hasan Genç*, Volkan Taşdemir, İsrafil Tozlu and Erdal Ögün  

Abstract:


4-benzoyl-1-(-4-methoxyphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid 2, obtained from 4-benzoyl-5-phenyl-2,3-furandione 1 and 4-methoxy benzaldehyde-phenyl hydrazone, was converted via reactions of its acid chloride 3 with various N-nucleophiles to the corresponding urea 8a−e or amide 6, and 7a−b derivatives, respectively. The amide 6 compound was converted to nitrite 9. Decarboxylation product 4, ester 5a−b, and cyclization products 10−12 with various hydrazines were obtained from the acid. The antimicrobial activities of the synthesized pyrazole carboxylic acid derivatives on Bacillus cereus, Escherichia coli, Micrococcus luteus, Staphylococcus aureus, and Saccharomyces cerevisiae were evaluated.

Keywords:

Cyclic oxalyl compounds, pyrazole, pyrazolopyridazinone, bioactivite

Affiliation:

Yüzüncü Yıl University, Faculty of Education, Department of Sciences, 65080, Van, Yuzuncu Yil University, Science Research and Application Center, 65080, Van, Yüzüncü Yıl University, Faculty of Education, Department of Sciences, 65080, Van, Yüzüncü Yıl University, Science Faculty, Biology Department, 65080



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