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Trifluoroacetylation of Anilines with Ethyl Trifluoropyruvate Mediated by Copper(I) Chloride

Author(s):

Jieyu Zhang, Qiumin Ke, Jiaying Chen, Jian Yu* and Guobing Yan*   Pages 1 - 5 ( 5 )

Abstract:


A novel copper(I)-mediated trifluoroacetylation of anilines with ethyl trifluoropyruvate as a trifluoroacetylating reagent has been developed. Although this protocol could provide the mediate to good yields in most cases, the reaction exhibited the obvious electronic and steric effects of substituents. The trace amount of products was only obtained for the substrates with ortho-substituted or electron-deficient groups.

Keywords:

Trifluoroacetylation, anilines, ethyl trifluoropyruvate, copper catalysis, cross-coupling

Affiliation:

Department of Chemistry, Lishui University, Lishui 323000, Department of Chemistry, Lishui University, Lishui 323000, Department of Chemistry, Lishui University, Lishui 323000, Department of Chemistry, Lishui University, Lishui 323000, Department of Chemistry, Lishui University, Lishui 323000



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