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Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives

Author(s):

Semra Karataş, İrfan Çapan and Süleyman Servi*   Pages 1 - 7 ( 7 )

Abstract:


Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or benzimidazole.

Keywords:

Dehydroepiandrosterone, indole, benzimidazole, 16-arylidene steroids

Affiliation:

Department of Chemistry, Faculty of Science, Firat University, Elazığ, Department of Polymer Technology, Technical Sciences Vocational College, Gazi University, Ankara, Department of Chemistry, Faculty of Science, Firat University, Elazığ



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