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Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives


Semra Karataş, İrfan Çapan and Süleyman Servi*   Pages 1 - 7 ( 7 )


Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or benzimidazole.


Dehydroepiandrosterone, indole, benzimidazole, 16-arylidene steroids


Department of Chemistry, Faculty of Science, Firat University, Elazığ, Department of Polymer Technology, Technical Sciences Vocational College, Gazi University, Ankara, Department of Chemistry, Faculty of Science, Firat University, Elazığ

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