Submit Manuscript  

Article Details


Synthesis of First Generation Dendron, GABA Caged Bis-1,2 -(4- acetylphenylethynyl)-4,5-dimethoxybenzene for Photorelease Study

[ Vol. 16 , Issue. 9 ]

Author(s):

André Barrella, Nia H. Rene, Kisha J. Ali, Jeonghee Kang and Jong I. Lee*   Pages 718 - 722 ( 5 )

Abstract:


First generation dendron bis-1,2-(4-acetylphenylethynyl)-4,5-dimethoxybenzene with a photo cleavable linkage to (t-butyloxycarbonyl-γ-aminobutyric acid (t-Boc-GABA) was synthesized for photo release study to apply for drug delivery. Both the divergent method from the core, 1,2- dimethoxybenzene and the convergent method from p-hydroxyacetophenone were not successful to generate the final dendron product. The dendron with caged GABA was successfully synthesized via the convergent method by attaching the model drug GABA on p-hydroxyacetophenone before the final Sonogashira coupling on 1,2-dimethoxybenzene according to the modified convergent method.

Keywords:

Phototrigger, dendrimer, dendron, drug delivery, GABA, convergent method.

Affiliation:

Department of Chemistry, York College, Jamaica, NY 11451, Department of Chemistry, York College, Jamaica, NY 11451, Department of Chemistry, York College, Jamaica, NY 11451, Department of Chemistry, St. Joseph's College, Brooklyn, NY 11250, Department of Chemistry, York College, Jamaica, NY 11451

Graphical Abstract:



Read Full-Text article