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Synthesis of First Generation Dendron, GABA Caged Bis-1,2 -(4acetylphenylethynyl)-4,5-dimethoxybenzene for Photorelease Study

[ Vol. 16 , Issue. 9 ]

Author(s):

André Barrella, Nia H. Rene, Kisha Jezel Ali, Jeonghee Kang and Jong I. Lee*   Pages 718 - 722 ( 5 )

Abstract:


First generation dendron bis-1,2-(4-acetylphenylethynyl)-4,5-dimethoxybenzene with a photo cleavable linkage to (t-butyloxycarbonyl-γ-aminobutyric acid (t-Boc-GABA) was synthesized for photo release study to apply for drug delivery. Both the divergent method from the core, 1,2-dimethoxybenzene and the convergent method from p-hydroxyacetophenone were not successful to generate the final dendron product. The dendron with caged GABA was successfully synthesized via the convergent method by attaching the model drug GABA on p-hydroxyacetophenone before the final Sonogashira coupling on 1,2-dimethoxybenzene according to the modified convergent method.

Keywords:

Phototrigger, dendrimer, dendron, drug delivery, GABA, convergent method.

Affiliation:

Department of Chemistry, York College, Jamaica, NY 11451, Department of Chemistry, York College, Jamaica, NY 11451, Department of Chemistry, York College, Jamaica, NY 11451, Department of Chemistry, St. Joseph`s College, Brooklyn, NY 11250, Department of Chemistry, York College, Jamaica, NY 11451



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