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K2CO3 Promoted Cascade Reaction for the Preparation of 1H-Imidazol-4- yl-1-amine Derivatives

Author(s):

Wei Xu, Hao Yao, Xing Zhang, Changjiang Peng, Ling Li, Yuanyuan Zhang, Shan Qian, Lingling Yang* and Zhouyu Wang*   Pages 1 - 6 ( 6 )

Abstract:


A K2CO3 promoted efficient one pot two steps method for the preparation of 1H-imidazol-4-yl-1-amine derivatives has been developed. A series of second amines with an imidazole group were obtained with 56%-91% yields by the K2CO3 promoted amination of acetates and nitrogen deprotection of the imidazole process.

Keywords:

one pot, second amine, imidazole´╝înucleophilic displacement

Affiliation:

Department of Pharmaceutics Engineering1, Xihua University, Chengdu, 610039, Department of Chemistry, Xihua University, Chengdu, 610039, Department of Chemistry, Xihua University, Chengdu, 610039, Department of Chemistry, Xihua University, Chengdu, 610039, Department of Pharmaceutics Engineering1, Xihua University, Chengdu, 610039, Department of Chemistry, Xihua University, Chengdu, 610039, Department of Pharmaceutics Engineering1, Xihua University, Chengdu, 610039, Department of Pharmaceutics Engineering1, Xihua University, Chengdu, 610039, Department of Chemistry, Xihua University, Chengdu, 610039



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