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Modular Synthesis of New Bicyclic Carbene Precursors

Author(s):

Jie Li, Jiaqi Yao, Weiping He, Fan Yang and Xiaoming Liu*   Pages 1 - 4 ( 4 )

Abstract:


A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2-c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave the desired bicyclic NHC precursors in good yields. The structures of these new NHC precursors were determined on the basis of spectroscopic techniques, including NMR and MS.

Keywords:

N-heterocyclic carbene, proline, synthesis, chirality

Affiliation:

Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, Department of Dermatology, The Third Af´Čüliated Hospital of Soochow University, No. 185, Juqian Street, Changzhou 213000



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