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Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins

Author(s):

Francisco J. Hidalgo, Nathan A.P. Lorentz, TinTin B. Luu, Jonathan D. Tran, Praveen D. Wickremasinghe, Olnita Martini, Peter M. Iovine and Joan G. Schellinger*   Pages 1 - 5 ( 5 )

Abstract:


Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.

Keywords:

Maltodextrin, dibromomaleimide, click chemistry, thiol release, sugar conjugates, 19F NMR.

Affiliation:

Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA, Department of Chemistry and Biochemistry University of San Diego, 5998 Alcala Park, San Diego, CA



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