Submit Manuscript  

Article Details


A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity

Author(s):

Haibo Wang and Xikui Liu*   Pages 1 - 5 ( 5 )

Abstract:


A novel bis-indole alkaloid was isolated from the flowers of Rauvolfia Yunnanensis Tsiang. Its structure was elucidated as 10,11´- dimethoxy-11,10´-bis-[N(a)-methyl deacetyldeformyl- 1,2- dihydro akuammiline(2β)] (1) on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESI-MS and comparison with data from the literature. The bis-indole alkaloid displayed more potent antihypertension activity and much lower hepatotoxicity in vivo than Reserpine.

Keywords:

Alkaloid, Bis-indole alkaloid, Rauvolfia yunnanensis, Rauvolfia flowers, Antihypertension, Reserpine.

Affiliation:

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Kunming 650204, Yunnan, P. R., State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Kunming 650204, Yunnan, P. R.



Read Full-Text article