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Synthesis and Characterization of Some New 1,3,4-thiadiazole Compounds Derived from 3,4-(Methylenedioxy)cinnamic Acid and their Antimicrobial Activities

[ Vol. 16 , Issue. 10 ]

Author(s):

Halit Muğlu, Mahmut Gür*, Maesm Ahmed Mohamed Ben Hsin, Nesrin Şener, Sevil Özkınalı, Osman Emre Özkan and İzzet Şener   Pages 825 - 836 ( 12 )

Abstract:


Some new 1,3,4-thiadiazole compounds derived from 3,4-(methylenedioxy)cinnamic acid were synthesized in this study. Their structures were determined using UV-Vis, IR, 1H-NMR, and 13CNMR spectroscopy. Moreover, the antibacterial activities of the new 1,3,4-thiadiazole derivatives were tested against Gram positive (Enterococcus durans, Bacillus subtilis, and Staphylococcus aureus) and gram negative (Salmonella typhimurium, Escherichia coli, Salmonella enteritidis, Salmonella infantis, Salmonella kentucky, Enterobacter aerogenes) bacteria using the disk diffusion method. Furthermore, their antifungal activity was tested against Candida albicans using the disk diffusion method. Some of the synthesized compounds (V, VII, XIII, and XIV) showed antibacterial activity against S. aureus. Also, one synthesized compound (VIII) showed antibacterial activity against E. coli, exhibiting 8 and 9 mm inhibition zones using 50 and 80 µL. One compound (IX) showed antibacterial activity against E. aerogenes, exhibiting a 12 mm inhibition zone using 80 µL. One compound (XIII) showed antibacterial activity against S. kentucky, exhibiting an inhibition zone of about 9 mm using 80 µL. Also, one compound (VII) showed antibacterial activity against E. durans, exhibiting 7, 7, and 8 mm inhibition zones using 30, 50, and 80 µL. None of the compounds (I-XV) showed antifungal activity against C. albicans. These results showed that some of the synthesized compounds could be used as antibacterial agents.

Keywords:

1, 3, 4-Thiadiazole, antimicrobial activity, IR and NMR spectroscopy, antibacterial activities, gram positive, gramnegative bacteria.

Affiliation:

Kastamonu University, Faculty of Science and Literature, Department of Chemistry, Kastamonu, Department of Forest Industrial Engineering, Faculty of Forestry, Kastamonu University, Kastamonu University, Faculty of Science and Literature, Department of Chemistry, Kastamonu, Kastamonu University, Faculty of Science and Literature, Department of Chemistry, Kastamonu, Hitit University, Faculty of Science and Literature, Department of Chemistry, Çorum, Department of Forest Industrial Engineering, Faculty of Forestry, Kastamonu University, Department of Food Engineering, Faculty of Engineering, Kastamonu University, Kastamonu



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