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Selective α,α-Dibromination of Arylethanones with Copper(II) Bromide

[ Vol. 16 , Issue. 9 ]

Author(s):

Jitander K. Kapoor, Loveena Arora* and Om Prakash   Pages 700 - 704 ( 5 )

Abstract:


Various arylethanones including electron-rich aromatic ketones such as o-hydroxyacetophenone and its p-isomer underwent selective side-chain α,α-dibromination using a heterogeneous system consisting of four molar equivalents of copper(II) bromide in chloroform-ethyl acetate under reflux. This study provides the cleanest method for the selective synthesis of several synthetically useful α,α-dibromoketones which are otherwise difficult to prepare.

Keywords:

o/p-Hydroxyacetophenone, heterogeneous system, side-chain dibromination, arylethanones, copper(II) bromide, bromoketone.

Affiliation:

Department of Chemistry, National Institute of Technology, Kurukshetra, Haryana, Department of Chemistry, National Institute of Technology, Kurukshetra, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana



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