Jitander K. Kapoor, Loveena Arora* and Om Prakash Pages 1 - 5 ( 5 )
Various arylethanones including electro-rich aromatic ketones such as o-hydroxyacetophenone and its p-isomer underwent selective side-chain α,α-dibromination using a heterogeneous system consisting of four molar equivalents of copper(II) bromide in chloroform-ethyl acetate under reflux. This study provides the cleanest method for the selective synthesis of several synthetically useful α,α-dibromoketones which are otherwise difficult to prepare.
o/p-Hydroxyacetophenone, heterogeneous system, side-chain dibromination, arylethanones, copper(II) bromide
Department of Chemistry, National Institute of Technology, Kurukshetra, Haryana, Department of Chemistry, National Institute of Technology, Kurukshetra, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana