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Synthesis and Anti Lung Cancer Activity of 3-Arylspiro[oxirane-2,3'- thiochroman]-4'-one Derivatives


Dhananjay Pandya and Yogesh Naliapara*   Pages 1 - 8 ( 8 )


A series of 3-arylspiro[oxirane-2,3'-thiochroman]-4'-one derivatives were synthesized and characterized by spectroscopy like 1H NMR, 13C NMR, mass spectrometry and elemental analysis. They were evaluated for their anti-lung cancer activity on human lung cancer cell line A-549 in DMSO. Compounds under study were found to be potent anti-lung cancer agents with GI50 values less than 10 with respect to positive control adriamycin.


Anti-cancer agents, Epoxides, Darzen Condensation, Human Lung Cancer Cell Line A-549, α, β-Epoxyketones


Department of Chemistry, Saurashtra University, Rajkot, Gujarat, Department of Chemistry, Saurashtra University, Rajkot, Gujarat

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