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Synthesis and Evaluation of Antioxidant, Antimicrobial and Anticancer Properties of 2-(prop-2-yn-1-yloxy)benzaldehyde Derivatives

Author(s):

Metin Konus*, Selahattin Aydemir, Can Yılmaz, Arif Kivrak, Aslıhan Kurt Kızıldogan and Pembegül Uyar Arpacı   Pages 1 - 9 ( 9 )

Abstract:


5-bromo-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 3) and 3,5-di-tert-butyl-2-(prop-2- yn-1-yloxy)benzaldehyde (compound 5) were synthesized via nucleophilic substitution reactions. Compound 5 showed higher antioxidant capacity with respect to compound 3 in all the four different antioxidant activity methods used. Moreover, in phosphomolybdenum assay, compound 5, with 1.1 proportion value, showed almost the same total antioxidant capacity compared to universal trolox standard. Furthermore, Broth microdilution method and agar disc diffusion tests demonstrated that the same compound also exhibited good antibacterial activity towards the bacteria Bacillus subtilis. Finally, both of the benzaldehyde compounds showed high antifungal activity against Aspergillus niger. In this study, compound 5 (IC50: 54.3 μg/ml) showed significant cytotoxic activity against breast adenocarcinoma cell line MCF-7 with respect to compound 3 (IC50: 173.4 μg/ml).

Keywords:

2-(prop-2-yn-1-yloxy)benzaldehyde, antioxidant, antibacterial, antifungal, anticancer, human breast carcinom2-(prop-2-yn-1-yloxy)benzaldehyde, human breast carcinoma

Affiliation:

Department of Molecular Biology and Genetics, Faculty of Science, Van Yüzüncü Yıl University, Van, Department of Molecular Biology and Genetics, Faculty of Science, Van Yüzüncü Yıl University, Van, Department of Molecular Biology and Genetics, Faculty of Science, Van Yüzüncü Yıl University, Van, Department of Chemistry, Faculty of Science, Van Yüzüncü Yıl University, Van, Enzyme and Microbial Biotechnology Section, Department of Agricultural Biotechnology, Faculty of Agriculture, Ondokuz Mayıs University, Samsun, Department of Biotechnology, Faculty of Science, Selçuk University, Konya



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