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Transition Metal-Free Trifluoroethoxylation of Diaryliodonium Salts and Fluoro Alcohols

Author(s):

Jian Li*, Zhengbing Wang, Xuechen Lu, Jing Lin, Li Liu and Yue Zhao   Pages 1 - 6 ( 6 )

Abstract:


A method for the synthesis of aryl trifluoroethyl ethers from fluoroalcohols and diaryliodonium salts in the presence of NaH and warm 1,2-dichloroethane has been developed. This transition metal free reaction is mild and facile. Various functional group including electron-withdrawing and electron-donating substrates in the diaryliodonium salts were tolerated in this transformation to afford the products in moderate to high yields.

Keywords:

Diaryliodonium salts, Metal-free, Trifluoroethoxylation

Affiliation:

School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, 213164, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093



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