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Microwave-Assisted Synthesis of Chiral Oxime Ethers

[ Vol. 16 , Issue. 6 ]

Author(s):

Asma Mehrez*, Dalila Mtat and Ridha Touati   Pages 495 - 500 ( 6 )

Abstract:


An efficient and rapid synthesis of a new class of chiral oxime ethers has been achieved via two-step reaction in which the first step is the reaction of oximes 1a-f with ethyl bromoacetate in the presence of sodium hydride to give oxime ethers 2a-f which are subsequently, in the second step, reacted with different commercially available chiral amines under microwave irradiation conditions to give compounds 3a-l in good to excellent yields. Through this method, we have observed a decrease in reaction time and excellent yields than the previously described conventional method.

Keywords:

Oxime ethers, chiral, achiral, microwave irradiation, biological activity, growth regulators.

Affiliation:

Laboratory of Asymmetric Organic Synthesis and Homogeneous Catalysis (UR11ES56), Faculty of Sciences of Monastir, Avenue of the Environment, 5019 Monastir, Laboratory of Asymmetric Organic Synthesis and Homogeneous Catalysis (UR11ES56), Faculty of Sciences of Monastir, Avenue of the Environment, 5019 Monastir, Laboratory of Asymmetric Organic Synthesis and Homogeneous Catalysis (UR11ES56), Faculty of Sciences of Monastir, Avenue of the Environment, 5019 Monastir



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