Submit Manuscript  

Article Details


Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

[ Vol. 16 , Issue. 6 ]

Author(s):

Pham Van Khang*, Nguyen Thi Hien Lan, Le Quang Truong, Mai Thi Minh Chau, Mai Xuan Truong, Dinh Thuy Van, Nguyen Thi Quynh Anh and Lei Ma*   Pages 474 - 477 ( 4 )

Abstract:


In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL, respectively.

Keywords:

Anemarrhena asphodeloides, steroidal glycosides, HeLa, A549, anti-proliferation, cell line.

Affiliation:

Faculty of Chemistry, TNU-University of Education, Thai Nguyen City, Faculty of Chemistry, TNU-University of Education, Thai Nguyen City, Faculty of Chemistry, TNU-University of Education, Thai Nguyen City, Faculty of Chemistry, TNU-University of Education, Thai Nguyen City, Faculty of Chemistry, TNU-University of Education, Thai Nguyen City, Faculty of Chemistry, TNU-University of Education, Thai Nguyen City, Department of Biology, TNUUniversity of Education, Thai Nguyen City, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237

Graphical Abstract:



Read Full-Text article