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Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

[ Vol. 16 , Issue. 6 ]

Author(s):

Pham Van Khang*, Nguyen Thi Hien Lan, Le Quang Truong, Mai Thi Minh Chau, Mai Xuan Truong, Dinh Thuy Van, Nguyen Thi Quynh Anh and Lei Ma   Pages 474 - 477 ( 4 )

Abstract:


In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 μg/mL, respectively.

Keywords:

Anemarrhena asphodeloides, steroidal glycosides, HeLa, A549, anti-proliferation, cell line.

Affiliation:

Faculty of Chemistry, TNU-University of Education, Thai Nguyen city, Faculty of Chemistry, TNU-University of Education, Thai Nguyen city, Faculty of Chemistry, TNU-University of Education, Thai Nguyen city, Faculty of Chemistry, TNU-University of Education, Thai Nguyen city, Faculty of Chemistry, TNU-University of Education, Thai Nguyen city, Faculty of Chemistry, TNU-University of Education, Thai Nguyen city, Department of Biology, TNU-University of Education, Thai Nguyen city, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237



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