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Synthesis of Novel 2-Amino-substituted 6-Methyl-pyrimidin-4-ol Derivatives and Their Biological Evaluation

Author(s):

Aleksandr P. Yengoyan, Vergush A. Pivazyan, Emma A. Ghazaryan and Zhermen A. Azaryan*   Pages 1 - 8 ( 8 )

Abstract:


A series of novel derivatives based on 2-amino-substituted 4-methylpyrimidin-4-ols were synthesized by simple, accessible and efficient methods. 4-N-triazolyl derivatives were obtained from the corresponding 4-chloro derivatives, and O-substituted products, including compounds with a combination of the pyrimidine and oxadiazole rings in the molecule, were synthesized from the sodium salts of 2-amino-substituted pyrimidin-4-ols. The synthesized compounds showed a pronounced stimulating action on plants growth. Their growth stimulant activities were in the range of 46-93% compared to heteroauxin.

Keywords:

O-substituted 2-amino-4-methylpyrimidin-4-ols, 4-triazolylaminopyrimidines, heterocyclization, 1.3.4-oxadiazolyl-alkyloxypyrimidines, plant growth stimulant activity

Affiliation:

Russian-Armenian University, H.Emin str., 123, 0051, Yerevan, National Agrarian University of Armenia, Teryan str., 74, 0009, Yerevan, National Agrarian University of Armenia, Teryan str., 74, 0009, Yerevan, Russian-Armenian University, H.Emin str., 123, 0051, Yerevan



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