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Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

[ Vol. 16 , Issue. 6 ]

Author(s):

Kenia Barrantes*, Mary Fuentes, Luz Chacon, Rosario Achi, Jorge Granados-Zuniga, Maria Jose Alvarado, Luis Somarribas, Jose Vazquez-Tato, M. Pilar Vazquez-Tato, Julio A. Seijas and Victor Soto Tellini   Pages 478 - 484 ( 7 )

Abstract:


Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

Keywords:

Surfactants, cytotoxic activity, antimicrobial activity, aromatic, 4-nitro-3-hidroxybenzoic acid, organic chemistry.

Affiliation:

Health Research Institute (INISA), University of Costa Rica, San Jose 2060, MHIRT Program, University of Texas at El Paso(UTEP), El Paso, TX 79968, Health Research Institute (INISA), University of Costa Rica, San Jose 2060, Health Research Institute (INISA), University of Costa Rica, San Jose 2060, School of Medicine, University of Costa Rica, San Jose 2060, School of Chemistry, University of Costa Rica, San Jose 2060, School of Medicine, University of Costa Rica, San Jose 2060, Facultad de Ciencias, Departamento de Quimica Organica, Universidad de Santiago de Compostela, Facultad de Ciencias, Departamento de Quimica Organica, Universidad de Santiago de Compostela, Facultad de Ciencias, Departamento de Quimica Organica, Universidad de Santiago de Compostela, School of Chemistry, University of Costa Rica, San Jose 2060



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