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A Novel One-pot Protocol for the Cu-Catalyzed Synthesis of Nine 2-Aminobenzimidazole Derivatives from o-Phenylenediamine and Trichloroacetonitrile

[ Vol. 16 , Issue. 2 ]


Manijeh Nematpour*, Elham Abedi and Elahe Abedi   Pages 99 - 103 ( 5 )


The synthesis of a variety of 2-aminobenzimidazoles via a one pot reaction of ophenylenediamine and trichloroacetonitrile catalyzed by copper (II) acetate in THF at room temperature, with good yields is described. Use of simple and readily available starting materials, good to high yields, free ligand, and no column chromatography are important features of this protocol.


Trichloroacetonitrile, copper (II) acetate, 2-aminobenzimidazoles, o-phenylenediamine, THF, ligand.


Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Pathology Department, Shiraz University of Medical Siences, Shiraz, Department of Food Sciences and Technology, Fasa University, Fasa

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